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AssigneePacific Biosciences of California, Inc.
InventorsStephen Yue, Gene Shen, Louis Brogley, Lubomir Sebo, Jeffrey Wegener
Estimating the term…
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an adaptor. An adaptor can be a component of a linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.
A fluorescent dye having the formula:
The fluorescent dye of any preceding claim, wherein A is a member selected from:
The fluorescent dye of any preceding claim, wherein A is a member selected from:
The fluorescent dye of any preceding claim, wherein A is a member selected from:
The fluorescent dye of any preceding claims in which said polyvalent moiety is a residue of a member selected from triazine, perylene, and tetra-aminoadamantane.
A method of monitoring an enzyme reaction, said method comprising:
Dependencies are inferred from the claim text.