Alkylated semi synthetic glycosaminoglycosan ethers, and methods for making and using thereof
AssigneeUniversity of Utah Research Foundation
InventorsGlenn D. Prestwich, Jianxing Zhang, Thomas P. Kennedy, Narayanam V. Rao
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Abstract
Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment.
Claims20
A method of treating, inhibiting, or preventing an ocular or ophthalmic condition in a subject, said method comprising administering an effective amount of a compound comprising a modified hyaluronan or the pharmaceutically acceptable salt or ester thereof comprising at least one sulfate group and at least one primary C-6 hydroxyl position of an N-acetyl-glucosamine residue comprising an unsubstituted C1-C10 alkyl group to a subject symptomatic of or predisposed to an ocular or ophthalmic condition associated with said ocular or ophthalmic condition.
A pharmaceutical composition for the treatment, prevention, or inhibition of an ocular or ophthalmic condition, said composition comprising a modified hyaluronan or the pharmaceutically acceptable salt or ester thereof comprising at least one sulfate group and at least one primary C-6 hydroxyl position of an N-acetyl-glucosamine residue comprising an unsubstituted C1-C10 alkyl group and one or more pharmaceutically acceptable carriers, wherein the pharmaceutical composition is formulated to be applied to directly to the eye and/or surrounding tissue of the eye.
A compound for the treatment, prevention, or inhibition of an ocular or ophthalmic condition associated with said ocular or ophthalmic condition, said compound comprising a modified hyaluronan or the pharmaceutically acceptable salt or ester thereof comprising at least one sulfate group and at least one primary C-6 hydroxyl position of an N-acetyl-glucosamine residue comprising an unsubstituted C1-C10 alkyl group.
Dependencies are inferred from the claim text.