Medical Devices and Polymers Therefor Having PTFE Surfaces Modified With Nitric Oxide-Releasing Polymers
AssigneeMedtronic Vascular, Inc.
InventorMingfei Chen
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Abstract
Described herein are polymers useful for forming or coating implantable medical devices and such medical devices. The polymers are biocompatible and hemocompatible and comprise PTFE surfaces modified by covalently linking a nitric oxide releasing polymer to the PTFE surface through a linking group. Further described are precursor polymers and processes for preparing such polymers and precursor polymers.
Claims26
A biocompatible and hemocompatible polymer adapted for use in an implantable medical device, comprising:
- a. a PTFE surface;
- b. a linking group covalently bound to said surface;
- and
- c. a nitric oxide releasing polymer, said polymer covalently bound to said linking group.
An implantable medical device comprising a biocompatible and hemocompatible polymer comprising:
- a. a PTFE surface;
- b. a linking group covalently bound to said surface;
- and
- c. a nitric oxide releasing polymer, said polymer covalently bound to said linking group.
A polymer adapted for use in an implantable medical device, comprising:
- a. a PTFE surface;
- b. a linking group covalently bound to said surface;
- and
- c. a diazeniumdiolatable polymer, said polymer covalently bound to said linking group.
An implantable medical device comprising a polymer comprising:
- a. a PTFE surface;
- b. a linking group covalently bound to said surface;
- and
- c. a diazeniumdiolatable polymer, said polymer covalently bound to said linking group.
A process for preparing a polymer of the formula
- wherein PTFE is polytetrafluoroethylene, PEI is poly(ethyleneimine), DZN is a diazeniumdiolate group (NONO) and n is an integer between 0 and 20, the process comprising:
- a. treating a PTFE surface with ammonia in a plasma discharge to form a compound of Formula 1;
- b. reacting the compound of Formula 1 with a diacyl dichloride
- Cl—C(O)—(CH2)n—C(O)—Cl
- wherein n is as above, to form a compound of Formula 2;
- c. reacting the compound of Formula 2 with a polymer comprising poly(ethyleneimine) to form a compound of Formula 3;
- and
- d. reacting the compound of Formula 3 with nitric oxide.
A process for preparing a polymer of the formula
- wherein PTFE is polytetrafluoroethylene, DZN is a diazeniumdiolated group (NONO), n is an integer between 0 and 20 and a and b are independently integers between about 1 and 20,000, the process comprising:
- a. treating a PTFE surface with ammonia in a plasma discharge to form a compound of Formula 1;
- b. reacting the compound of Formula 1 with a diacyl dichloride
- Cl—C(O)—(CH2)n—C(O)—Cl
- wherein n is as above, to form a compound of Formula 2;
- c. reacting the compound of Formula 2 with a copolymer comprising vinyl alcohol and vinyl acetate monomeric units
- wherein a and b are as above, to form a compound of Formula 6;
- and
- d. reacting the compound of Formula 6 with nitric oxide.
Dependencies are inferred from the claim text.