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US 2011/0301211 A1Published application
Antagonists of lysophosphatidic acid receptors
OwnerJohn Howard Hutchinson, Thomas Jon Seiders +4inventors
InventorsJohn Howard Hutchinson, Thomas Jon Seiders, Bowei Wang, Jeannie M. Arruda, Jeffrey Roger Roppe, Timothy Parr
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Abstract
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
Claims15
A compound having the structure of Formula (I) or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is —CO2H, —CO2RD, —CN, tetrazolyl, —C(═O)NH2, —C(═O)NHR10, —C(═O)NHSO2R10 or —C(═O)NHCH2CH2SO3H;
- RD is H or C1-C4alkyl;
- L1 is absent or C1-C6alkylene;
- R3 is H, C1-C4alkyl, C3-C6cycloalkyl, or C1-C4-fluoroalkyl;
- R7 is H or C1-C4alkyl;
- R8 is H, C1-C4alkyl, or C1-C4-fluoroalkyl;
- R10 is a C1-C6alkyl, C1-C6-fluoroalkyl, C3-C6cycloalkyl, or a substituted or unsubstituted phenyl;
- each of RA, RB, and RC are independently selected from H, F, Cl, Br, I, —CN, —OH, C1-C4alkyl, C1-C4-fluoroalkyl, C1-C4-fluoroalkoxy, C1-C4alkoxy, and C1-C4heteroalkyl;
- m is 0, 1, or 2;
- n is 0, 1, or 2;
- p is 0, 1, or 2.
9 more elements
Dependencies are inferred from the claim text.