Modified release preparations containing oxcarbazepine and derivatives thereof
AssigneeSupernus Pharmaceuticals, Inc.
InventorsPadmanabh P. Bhatt, Argaw Kidane, Kevin Edwards
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Abstract
Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
Claims26
A method of treating seizures, comprising administering to a subject in need thereof a pharmaceutical formulation comprising multiple units, wherein each unit comprises a homogeneous mixture of (a) oxcarbazepine, (b) at least one agent that enhances solubility of oxcarbazepine, and (c) at least one release promoting agent, wherein said release promoting agent comprises a polymer having pH-dependent solubility, and wherein each unit has a release profile for the oxcarbazepine different from other units.
A method of treating seizures, comprising administering to a subject in need thereof a pharmaceutical formulation comprising multiple units, wherein each unit comprises a homogeneous mixture of (a) oxcarbazepine, (b) at least one agent that enhances solubility of oxcarbazepine, and (c) at least one release promoting agent, wherein said release promoting agent comprises a polymer having pH-dependent solubility, wherein each unit has a release profile for the oxcarbazepine different from other units, and wherein the amount of oxcarbazepine is effective to produce a steady state blood level of monohydroxy derivative of oxcarbazepine in the range of about 2 μg/ml to about 10 μg/ml.
A method of treating seizures, comprising administering to a subject in need thereof a pharmaceutical formulation comprising multiple units, wherein each unit consists essentially of a matrix comprising a homogenous mixture of oxcarbazepine, at least one agent that enhances solubility of oxcarbazepine, and at least one release promoting agent, wherein said release promoting agent comprises a polymer having pH-dependent solubility and wherein each unit has a release profile for the oxcarbazepine different from other units.
Dependencies are inferred from the claim text.