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US 2011/0301104 A1Published application
Transition state structure of orotate phosphoribosyl transferases and uses thereof
OwnerVern L. Schramminventor
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Abstract
Methods are provided for designing a transition state inhibitor of orotate phosphoribosyltransferase (OPRT) and for inhibiting OPRT.
Claims15
A method for designing a transition state inhibitor of orotate phosphoribosyltransferase (OPRT) comprising designing a compound that resembles the charge and geometry of the OPRT transition state.
Dependencies are inferred from the claim text.