Dedifferentiation and reprogramming of cells
OwnerGeorge L. Singinventor
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Abstract
The invention is directed to methods for reprogramming somatic cells to a less differentiated state. In particular, the invention is directed to methods for reprogramming amnion epithelial cells (AEC) including amnion-derived cells (ADC) and Amnion-derived Multipotent Progenitor cells (AMP cells) to a less differentiated state. The invention is further directed to compositions comprising reprogrammed AEC, ADC and AMP cells, and uses thereof.
Claims22
1-33. (canceled)
A composition comprising reprogrammed amnion epithelial cells (AECR), reprogrammed amnion-derived cells (ADCR), or reprogrammed Amnion-derived Multipotent Progenitor (AMPR) cells, or a combination thereof, wherein the cells exhibit pluripotency characteristics.
A composition comprising AECR, ADCR or AMPR cells, or a combination thereof, wherein the cells are capable of differentiating into any cell type which arises from the endoderm, mesoderm, or ectoderm.
A method of reprogramming AEC, ADC, or AMP cells to a less differentiated state comprising contacting the cells with an agent capable of effecting such reprogramming.
Dependencies are inferred from the claim text.