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US 2011/0300626 A1Published application
Electrospun Ceramic-Polymer Composite As A Scaffold for Tissue Repair
AssigneeNew Jersey Institute of Technology
InventorTreena Lynne Arinzeh
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Abstract
The present invention relates to compositions and methods of preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a bioactive ceramic component and a polymer component. The matrix provides an osteoconductive and osteoinductive scaffold supporting osteogenesis and thereby facilitates bone repair.
Claims23
1-25. (canceled)
A method of preparing an osteoinductive and osteoconductive scaffold to facilitate bone repair, the method comprising the steps:
- (a) preparing a ceramic-polymer composite comprising a bioactive ceramic component and a polymer component;
- and
- (b) electrospinning the ceramic-polymer composite, thereby depositing a three-dimensional nonwoven matrix of micron sized electrospun fibers comprising the ceramic-polymer composite on a collector, the three dimensional-nonwoven matrix of electrospun fibers including a plurality of micron sized pores, each micron sized pore of the plurality of micron sized pores having a pore size of at least about 20 microns in diameter.
(canceled)
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Dependencies are inferred from the claim text.