Diagnosis of pre-eclampsia
AssigneePerkinElmer LAS, Inc.
InventorsLucilla POSTON, Paul Townsend SEED, Beverley Jane HUNT, Lucy Charlotte Chappell
Life of this patent
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Abstract
The present invention relates to a method of predicting pre-eclampsia (PE). The present invention also relates to a diagnostic kit for performing a method of predicting PE. In particular, the method determining the level of two or more markers selected from placenta growth factor (PlGF), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2 (PAI-2) and leptin.
Claims29
A method of specific prediction of pre-eclampsia (PE) comprising determining in a maternal sample the level of two or more markers selected from placenta growth factor (PlGF), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2 (PAI-2) and leptin.
The method according to any one of the preceding claims, wherein the maternal sample is blood.
The method according to any one of the preceding claims, wherein the maternal sample is taken between 12 and 38 weeks.
A diagnostic kit for performing the method of any one of the preceding claims, wherein the kit comprises reagents required to determine the level of the markers being measured.
A method of specific prediction of pre-eclampsia which comprises determining in a maternal blood sample or other body fluid the level of placenta growth factor (PlGF) in combination with the level of one or more factors selected from the following list:
- i. plasminogen activator inhibitor-1 (PAI-1) ii. plasminogen activator inhibitor-2 (PAI-2), and iii. leptin
A method of specific prediction of pre-eclampsia which comprises testing a maternal blood sample or other body fluid using as markers a combination of placenta growth factor (PlGF) with one of the following:
- i. plasminogen activator inhibitor-2 (PAI-2) ii. the ratio of plasminogen activator inhibitor-1 (PAI-1) to plasminogen activator inhibitor-2 (PAI-2) i.e. PAI-1/PAI-2, and iii. the ratio leptin/PlGF.
Dependencies are inferred from the claim text.