Sub-micron surface plasmon resonance sensor systems
AssigneeIndiana University Research and Technology Corporation
InventorsJames A. Glazier, Dragos Amarie
Life of this patent
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Abstract
Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
Claims39
A wearable device for monitoring the concentration of one or more target analytes, ligands, or molecules in a body fluid comprising:
- a conduit adapted to connect to the patient's bodily fluid;
- and;
- a sensor chip, wherein the sensor chip comprises
- a light transmissive substrate;
- a housing formed of a light transmissive material and defining at least one fluid cavity in communication with at least one fluid inlet for receiving the body fluid and at least one fluid outlet;
- one or more micro-cavity surface plasmon resonance (MSPR) sensors mounted on a surface of the light transmissive substrate;
- a light source arranged to direct light toward the MSPR sensors;
- and
- a detector arranged relative to the one or more MSPR sensors to detect their emitted light;
- wherein the one or more MSPR sensors are mounted randomly or non-randomly over a spatial domain of said surface;
- an exposed surface of each MSPR sensor is functionalized with a surface treatment, or a surface coating of a material capable of binding with the one or more targets to be detected;
- each MSPR sensor includes a light transmissive core formed in a geometric shape that can sustain periodic boundary conditions for a stationary surface plasmon waves to travel across the outer surface thereof;
- and a pinhole is defined at the interface between each MSPR sensor and the substrate;
- and
- the conduit is in communication with at least one of the fluid inlets.
An implantable device for monitoring the concentration of one or more target analytes, ligands, or molecules in a body fluid comprising:
- a conduit adapted to connect to the patient's bodily fluid;
- and;
- a sensor chip, wherein the sensor chip comprises
- a light transmissive substrate;
- a housing formed of a light transmissive material and defining at least one fluid cavity in communication with at least one fluid inlet for receiving the body fluid and at least one fluid outlet;
- one or more micro-cavity surface plasmon resonant (MSPR) sensors mounted on a surface of the light transmissive substrate;
- a light source arranged to direct light toward the MSPR sensors;
- and
- a detector arranged relative to the one or more MSPR sensors to detect emitted light;
- wherein the one or more MSPR sensors are mounted randomly or non-randomly over a spatial domain of said surface;
- an exposed surface of each MSPR sensor is functionalized with a surface treatment, or a surface coating of a material capable of binding with the one or more targets to be detected;
- each MSPR sensor includes a light transmissive core formed in a geometric shape that can sustain periodic boundary conditions for a stationary surface plasmon waves to travel across the outer surface thereof;
- and a pinhole is defined at the interface between each MSPR sensor and the substrate;
- and
- the conduit is in communication with at least one of the fluid inlets.
Dependencies are inferred from the claim text.