Benzylthiotetrazole inhibitors of store operated calcium release

A compound of Formula (I):

• wherein:
• X is H, C(O)NR3R4, C(O)OR4, C(O)R4, NR3C(O)NR3R4, C(O)NR3—C(O)NR3R4, CH2NHSO2-aryl, C1-C6alkyl, C1-C6alkenyl, C1-C6heteroalkyl or aryl;
• wherein C1-C6alkyl, C1-C6alkenyl, C1-C6heteroalkyl and aryl is optionally substituted with at least one R5;
• or
• when X is C(O)NR3R4, then R3 and R4 together with the nitrogen atom to which they are attached form a C2-C6heterocycloalkyl;
• Y is H, C1-C6alkyl, C1-C6alkenyl, C1-C6heteroalkyl;
• wherein C1-C6alkyl, C1-C6alkenyl, C1-C6heteroalkyl is optionally substituted with at least one Rs;
• R1 and R2 are each independently H, F, Cl, Br, I, —CN, —NO2, —OH, —CF3, —OR9, C1-C6alkyl, C3-C8cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C8heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl, —NHS(═O)2R8, —S(═O)2N(R9)2, —N(R9)S(═O)2N(R9)2, —C(═O)CF3, —C(═O)NHS(═O)2R8, —S(═O)2NHC(═O)R8, —N(R9)2, —N(R9)C(═O)R8, —N(R9)C(═O)N(R9)2, —N(R9)C(═O)OR8, —CO2R9, —C(═O)R8, —OC(═O)R8, —OC(═O)N(R9)2, —CON(R9)2, —SR8, —S(═O)R8, and —S(═O)2R8;
• or
• two R2 and the carbon atoms to which they are attached form
• R3 is selected from H, C1-C6alkyl, C1-C6alkenyl, C1-C6heteroalkyl, C3-C8cycloalkyl;
• R4 is selected from H, aryl or heteroaryl;
• wherein aryl or heteroaryl is optionally substituted with at least one R5;
• R5 is selected from F, Cl, Br, I, —CN, —NO2, —OH, —CF3, —OR9, C1-C6alkyl, C3-C8cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C8heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl, —NHS(═O)2R8, —S(═O)2N(R9)2, —N(R9)S(═O)2, N(R9)2, —C(═O)CF3, —C(═O)NHS(═O)2R8, —S(═O)2NHC(═O)R8, —N(R9)2, —N(R9)C(═O)R8, —N(R9)C(═O)N(R9)2, —N(R9)C(═O)OR8, —CO2R9, —C(═O)R8, —OC(═O)R8, —OC(═O)N(R9)2, —CON(R9)2, —SR8, —S(═O)R8, and —S(═O)2R8;
• n is an integer from 0-5;
• m is an integer from 0-5;
• each R8 is independently selected from C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl;
• each R9 is independently selected from H, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl;
• or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or pharmaceutically acceptable prodrug thereof.