Novel imidazo[1,2-a]pyridine derivatives, method for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use in particular as met inhibitors

A product of formula (I):

• in which:
• Ra represents a hydrogen atom;
• a halogen atom;
• an aryl radical;
• or a heteroaryl radical, these aryl and heteroaryl radicals being optionally substituted as indicated hereinafter;
• Rb represents a hydrogen atom, an Rc, —COORc or —CO-Rc radical or a —CO—NRcRd radical;
• where Rc represents an alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl radical, all these radicals being optionally substituted as indicated hereinafter;
• Rd represents a hydrogen atom or an alkyl or cycloalkyl radical;
• all the alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl radicals defined above being optionally substituted with one or more radicals chosen from halogen atoms, and the radicals:
• hydroxyl, alkoxy, CN, CF3, —NR1R2, —COOH, —COOalk, —CONR1R2, —NR1COR2, COR1, oxo and heterocycloalkyl, itself optionally substituted with one or more radicals chosen from halogen atoms, and hydroxyl, alkoxy, alkyl, CN, CF3, —NR3R4, COOH, —COOalk, —CONR3R4, —NR3COR4, —COR3 and oxo radicals;
• the alkyl and cycloalkyl radicals also being optionally substituted with an aryl or heteroaryl radical, themselves optionally substituted with one or more radicals chosen from halogen atoms and hydroxyl, alkyl, alkoxy and NR3R4 radicals;
• the cycloalkyl, heterocycloalkyl, aryl or heteroaryl radicals also being optionally substituted with an alkyl radical, itself optionally substituted with one or more radicals chosen from halogen atoms and hydroxyl, alkyl, alkoxy and NR3R4 radicals;
• NR1R2 being such that:
• either, R1 and R2 being identical or different, one of R1 and R2 represents a hydrogen atom or an alkyl radical and the other of R1 and R2 represents a hydrogen atom, or a cycloalkyl radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy, NR3R4, heterocycloalkyl, heteroaryl or phenyl radicals, themselves optionally substituted with one or more radicals chosen from halogen atoms and hydroxyl, alkyl, alkoxy, NH2, NHalk and N(alk)2 radicals;
• or R1 and R2 form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, N and NH, this radical, including the possible NH that it contains, being optionally substituted;
• NR3R4 being such that:
• either, R3 and R4 being identical or different, one of R3 and R4 represents a hydrogen atom or an alkyl radical and the other of R3 and R4 represents a hydrogen atom, or a cycloalkyl radical or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from hydroxyl, alkoxy, heterocycloalkyl, heteroaryl or phenyl radicals, themselves optionally substituted with one or more radicals chosen from halogen atoms and hydroxyl, alkyl, alkoxy, NH2, NHalk and N(alk)2 radicals;
• or R3 and R4 form, with the nitrogen atom to which they are attached, a cyclic radical containing from 3 to 10 ring members and optionally one or more other heteroatoms chosen from O, S, N and NH, this radical, including the possible NH that it contains, being optionally substituted;
• the cyclic radicals that R1 and R2 or R3 and R4, respectively, can form, with the nitrogen atom to which they are attached, being optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms, hydroxyl, oxo, alkoxy, NH2, NHalk and N(alk)2 radicals, and alkyl, phenyl, CH2-phenyl and heteroaryl radicals, such that, in the latter radicals, the alkyl, phenyl and heteroaryl radicals are themselves optionally substituted with one or more radicals chosen from halogen atoms and the radicals:
• hydroxyl, alkyl and alkoxy containing from 1 to 4 carbon atoms, NH2, NHalk and N(alk)2;
• all the alkyl (alk) and alkoxy radicals above containing from 1 to 6 carbon atoms;
• racemic, enantiomeric and diastereoisomeric isomers, and pharmaceutically acceptable salts thereof.