Dipeptidyl peptidase iv inhibitors

Compound of formula (I),

• their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof;
• wherein Y represents —O—, —S(O)p—, —CH2—, —CHOH—, —CHF— or —CF2—;
• m, n and p are integers independently selected from 0, 1 or 2;
• X represents a bond, C1-C5 alkylene or —C(═O)—;
• R1 represents hydrogen, optionally substituted groups selected from alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, heteroaryl, heterocyclyl, heterocycloalkyl, heterocyclylalkyl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, —N3, —S(O)pR10, —NR10S(O)pR11, —CN, —COOR10, —CONR10R11, —NR10R11 or —NR10COR11 or a group selected from:
• R12 represents hydrogen or substituted or unsubstituted groups selected from alkyl, alkoxy, acyl, hydroxylalkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heterocyclic ring, heterocycloalkyl, heterocyclylalkyl, heteroarylalkyl, carboxylic acid or carboxylic acid derivatives selected from esters, amides, acid halides, hydroxamic acid and hydroxamates;
• R2, R3 and R4 independently represents hydrogen, hydroxy, halogen, alkyl, haloalkyl, cyano, hydroxyalkyl, alkoxy, alkylsulfonyl, alkylthio, phenyl-S(O)p-alkyl, amino, —NR10R11 or phenylalkyl, wherein said phenyl is optionally substituted independently with one or more alkyl, cycloalkyl, alkoxy, cyano, halogen, alkylsulfonyl, alkylthio, —CO2alkyl, COOH, —CONH2, —CHO, —CH2OH, hydroxyl, haloalkyl, amino, nitro or R2 and R4 can be combined together to form an optionally substituted 4-10 membered ring having 0-4 hetero atoms selected from N, O and S;
• R5 represents hydrogen or optionally substituted alkyl group;
• R6 represents hydrogen or optionally substituted groups selected from alkyl, alkoxyalkyl, hydroxyalkyl, amino, R9NHalkyl and R9NHC(NH)NHalkyl;
• R7 and R9 independently represents hydrogen, alkyl or hydroxyl;
• R8 is hydrogen, —CN, —COOH, or an isosterate of a carboxylic acid comprising SO3H, B(OH)2, PO3R10R11, SO2NR10R11, tetrazole, —COOR10, —CONR10R11, —NR10COR11 and —COOCOR10;
• R10 and R11 independently represents hydrogen, nitro, hydroxy, cyano, formyl, acetyl, halogen or optionally substituted groups selected from amino, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heterocyclyl, heterocycloalkyl, heterocyclylalkyl, heteroarylalkyl, carboxylic acid or carboxylic acid derivatives selected from esters, amides, acid halides, hydroxamic acid and hydroxamates;
• when the groups R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are substituted or when the term “substituted” is used, the substituents are one or more and are selected from halogens, hydroxy, nitro, cyano, azido, nitroso, oxo (═O), thioxo (═S), thioalkyl, amino, hydrazino, formyl, alkyl, haloalkyl, alkoxy, haloalkoxy, arylalkoxy, cycloalkyl, cycloalkyloxy, aryl, heterocycloalkyl, heteroaryl, alkylamino, tolyl, —COORa, —C(O)Ra, —C(S)Ra, —C(O)NRaRb, —C(S)NRaRb, —NRaC(O)NRbRc, —NRaC(S)NRbRc, —N(Ra)SORb, —N(Ra)SO2Rb, —NRaC(O)ORb, —NRaRb, —NRaC(O)Rb, —NRaC(S)Rb, —SONRaRb, —SO2NRaRb, —ORa, —ORaC(O)ORb, —OC(O)NRaRb, —OC(O)Ra, —RaNRbRc, —RaORb, —SRa, —SORa and —SO2Ra;
• the substituents are further optionally substituted by one or more substituents as defined above;
• wherein Ra, Rb and Rc independently represents hydrogen or substituted or unsubstituted groups selected from alkyl, alkylene, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, cycloalkyl and cylcoalkenyl;
• or Ra and Rb can be combined together to form a ring structures having 4-8 atoms.