US 2011/0257134 A1Published application

CO-CRYSTALS OF TRAMADOL AND NSAIDs

AssigneeLaboratorios Del Dr. Esteve, S.A.

InventorsHelmut Heinrich Buschmann, Lluis Sola Carandell, Jordi Benet Buchholz, Jordi Carles Ceron Bertran, Carlos Ramon Plata Salaman, Nicolas Tesson

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Abstract

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same, their uses in pharmaceutical formulations, and for the treatment of various disorders, including pain.

Claims24

Dependent claims

A co-crystal comprising tramadol either as a free base or as a physiologically acceptable salt and at least one NSAID.

Dependencies are inferred from the claim text.

Facts

Application: 13/124,027Filed 16 Oct 2009
Priority: EP 08384012.417 Oct 2008
Published: 20 Oct 2011
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61K 31/635
Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide: having a heterocyclic ring, e.g.…
A61K 9/16
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: agglomerates;…
A61K 31/135
Amines: having aromatic rings , e.g. ketamine, nortriptyline
A61K 31/137
Having aromatic rings , e.g. ketamine, nortriptyline: arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone

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