Loading patent…
AssigneesUniversite De Liege, Universite Libre de Bruxelles
InventorsPhilippe Neven, Didier Serteyn, Jacques Delarge, Eva Scheer, Robert Kiss, Veronique Mathieu, Didier Cataldo, Natacha Rocks
Estimating the term…
The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumour and/or anti-inflammatory activity, and improved physico-chemical properties. In a second aspect, the present invention relates to a method for preparation of said water soluble curcumin derivatives. The invention further relates in a third aspect to a pharmaceutical composition comprising an effective amount of said water soluble curcumin derivatives. In a fourth aspect, the present invention concerns the use of said water soluble cucumin derivatives as a medicament and the use of said water soluble curcumin derivatives for the preparation of a medicament for the treatment of cancer and inflammatory diseases. In a fifth aspect, the present invention relates to the use of a pharmaceutical composition comprising said water soluble curcumin derivatives in the treatment of cancer and inflammatory diseases and to a new pharmaceutical composition comprising said water soluble curcumin derivatives.
A water soluble curcumin compound for treating proliferative and/or inflammatory disorders, characterised in that the compound is a cyclodextrin complex of a curcumin compound of general formula I:
The water soluble curcumin compound of any of the preceding claims characterised in that it is the acylated derivative of curcumin or, a derivative thereof or a glycosylated derivative of said compound.
A Process for producing a soluble HP-beta-CD-curcumin or HP-gamma-CD-curcumin compound, comprising the following steps:
Dependencies are inferred from the claim text.