Olive compositions and methods for treating inflammatory conditions
AssigneesArizona Board of Regents for and on behalf of Arizona State University, CreAgri, Inc.
InventorsKathleen Matt, Catherine M. Bitler, Roberto Crea
Life of this patent
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Abstract
A method of treating an inflammatory condition with a hydroxytyrosol-rich composition. Improvement is monitored as a reduction in the levels of a biochemical marker such as homocysteine or C-reactive protein. The composition may be administered in an amount and for a period sufficient to effect a drop in the level of the biochemical marker.
Claims26
A method of treating an inflammatory condition in a human subject, comprising:
- administering a hydroxytyrosol-rich composition to the subject,
- monitoring improvement in the subject according to a reduction in the subject's homocysteine levels, and
- continuing said administering in an amount and for a period sufficient to effect a drop in homocysteine level of at least 7.5%.
A method for reducing homocysteine plasma levels in a subject at risk of an inflammatory disease associated with elevated homocysteine levels, comprising:
- administering a hydroxytyrosol-rich composition to the subject in an amount and for a period effective to reduce plasma homocysteine levels to within a normal range of homocysteine.
A method for reducing the risk of cardiovascular disease in a patient having elevated plasma homocysteine levels, comprising:
- administering a hydroxytyrosol-rich composition to the subject at a dose and for a period effective to reduce patient plasma homocysteine to within a normal range of homocysteine.
A method for reducing the risk of cardiovascular disease in a subject having elevated plasma C-reactive protein (CRP) levels, comprising:
- administering a hydroxytyrosol-rich composition to the subject at a dose and for a period effective to reduce patient CRP levels to within a normal range.
A method of identifying, from a population of human subjects having an elevated plasma homocysteine level related to an inflammatory condition, those responsive subjects who will show the greatest response to treatment by oral administration of a hydroxytyrosol-rich composition, comprising
- administering the hydroxytyrosol-rich composition at a dose and for a period effective to substantially lower the plasma homocysteine level in a responsive subject,
- monitoring the subject's homocysteine level, and
- identifying the subject as a responsive subject if the subject's homocysteine level has decreased to within a normal range.
A method of treating an inflammatory condition in a human subject, comprising:
- administering a hydroxytyrosol-rich composition to the subject,
- monitoring improvement in the subject according to a reduction in the subject's C-reactive protein (CRP) levels, and
- continuing said administering in an amount and for a period sufficient to effect a drop in CRP level of at least 50%.
Dependencies are inferred from the claim text.