Use of drugs that activate p2y receptors to enhance synaptogenesis
AssigneeBack Bay Scientific, LLC
InventorRichard WURTMAN
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Abstract
The present invention encompasses compositions and methods that activate P2Y receptors for the increased production of new synapses in the central nervous system. The formulations of the invention may be administered to a healthy subject or to a subject in need thereof to restore synapses.
Claims26
A composition comprising at least one active agent that activates P2Y receptors in an amount sufficient to improve cognitive or neurological function in a subject.
A method for improving cognitive or neurological function in a subject comprising administering a therapeutically effective amount of at least one active agent that activates P2Y receptors to a subject in need thereof.
A method for increasing the level of synaptic proteins in a subject comprising administering a composition having at least one active agent, wherein the synaptic protein is NF-70, NF-M, PSD-95, or mGluR.
A method for screening in vitro a drug for enhancing brain synaptogenesis and/or activating brain P2Y receptors comprising incubating neuron-derived cells with the drug and determining the effect of the drug on the level of synaptic proteins and neurites in the cell.
Dependencies are inferred from the claim text.