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US 2011/0257086 A1Published application
Methods for synthesis and uses of inhibitors of ghrelin o-acyltransferase as potential therapeutic agents for obesity and diabetes
AssigneeThe Johns Hopkins University
InventorsPhilip A. Cole, Bradley P. Barnett, Yousang Hwang, Jef D. Boeke
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Abstract
The invention provides inhibitors of ghrelin O-acyltransferase, and methods of making and using them. In some embodiments, the invention provides bisubstrate analog inhibitors of ghrelin O-acyltransferase, which can be effective in treating, for example, obesity and diabetes mellitus.
Claims26
A compound of the formula (I) (SEQ ID NO:
- 1):
- wherein R is absent, or is an organic moiety selected from the group consisting of a substituted or unsubstituted alkyl group, a substituted or unsubstituted peptide chain, and a substituted or unsubstituted polysaccharide.
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Dependencies are inferred from the claim text.