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AssigneeInstraction GmbH
InventorKlaus Gottschall
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A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii): (i) determining at least two groups capable of binding a sorbent from a synthetic or natural first substrate, (ii) respectively applying at least two different groups capable of binding a second synthetic or natural substrate to one respective carrier, thereby forming at least one sorbent, whereby the groups are the same groups of step (i) or are groups that are complementary thereto, and the second substrate of step (ii) is the same or different from the first substrate according to step (i), and whereby the groups are determined such that the contributions of the Gibbs energies of the individual groups to the non-covalent bond with the second substrate yield a negative value of the Gibbs energy ΔG, such that a binding strengthening occurs that results in an improved separation selectivity with respect to at least one substance to be separated off.
A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii):
A method for the selectively binding of a substrate having at least two different groups, which are capable of binding, to at least one sorbent, characterized in that it comprises the steps (i) to (iv):
A method according to any one of the preceding claims, characterized in that the at least one first substrate is the same as the at least one second substrate, and the at least two different groups capable of binding the second substrate, respectively, are selected among those groups that are complementary to the groups which are determined in step (i).
A method according to any one of the preceding claims, characterized in that the selection of at least two groups capable of binding a sorbent from a synthetic or a natural first substrate in step (i) yields two components each having at least one group capable of binding the sorbent, and in step (ii) one sorbent is obtained;
A method according to any one of the preceding claims, characterized in that the at least two different groups capable of binding of the at least one sorbent are selected among groups which are part of amino acids, sugars, nucleotides, nucleosides, pyrimidine bases and purine bases.
A method according to any one of the preceding claims, characterized in that the at least two different groups capable of binding of the at least one second substrate are selected among groups which are part of amino acids, sugars, nucleotides, nucleosides, pyrimidine bases and purine bases.
A method according to any one of the preceding claims, characterized in that the at least two different groups in step (ii), respectively, are covalently bonded to a polymer.
A method according to any one of the preceding claims, characterized in that it additionally comprises the step (v):
A method according to any one of the preceding claims, characterized in that it additionally comprises the step (vi):
A method according to any one of the preceding claims, characterized in that the substrate comprises one or more natural agents selected from the group comprising amino acids, oligopeptides, nucleotides, proteins, glycoproteins, antigens, antibodies, carbohydrates, enzymes, co-enzymes, hormones, alkaloids, steroids, viruses, microorganisms, substances contained in vegetable and animal tissue, cells, cell fragments, cell compartments, cell disruptions, lectins, flavylium compounds, flavones, and isoflavones, or one or more synthetic agents selected from the group of substances having influence on the nervous system, having influence on the hormone system, having influence on mediators, having influence on the cardio-vascular system, having influence on the respiratory tract, having influence on the gastrointestinal tract, having influence on the kidney and the lower urinary tract, having influence on the eye, having influence on the skin, substances for the prophylaxis and therapy of infection diseases, having influence on malignant tumors, having influence on the immune system and substances having immunological influence, as well as insecticides, herbicides, pesticides and fungicides.
A combinatorial library comprising a collection of sorbents having at least two different first groups, respectively, that are capable of non-covalently binding at least one substrate having at least two different second groups, whereby the at least two different first groups are selected such that the contributions of the Gibbs energies of the individual first groups to the non-covalent bond with the at least two different second groups yield a total of a negative value of the Gibbs energy ΔG, such that a binding strengthening occurs which results in an improved separation selectivity with respect to at least one substance to be separated off.
A sorbent/substrate complex comprising at least one sorbent and at least one substrate, having at least two different second groups, whereby said sorbent has at least two different first groups capable of non-covalently binding the at least one substrate having the at least two different second groups, whereby the at least two first groups are selected such that the contributions of the Gibbs energies of the individual first groups to the non-covalent bond with the at least two different second-groups yield a total of a negative value of the Gibbs energy ΔG, such that a binding strengthening occurs which results in an improved separation selectivity with respect to at least one substance to be separated off.
Dependencies are inferred from the claim text.