Methods for diagnosis and treatment of neurodegenerative diseases or disorders
OwnerEric A. SCHON, Estela AREA-GOMEZ +1inventors
InventorsEric A. SCHON, Estela AREA-GOMEZ, Michael P. YAFFE
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Abstract
The present invention provides methods that are useful for the diagnosis of neurodegenerative disease or disorder and for the screening of compounds or therapeutic agents for treating a neurodegenerative disease or disorder. The methods pertain in part to the correlation of a neurodegenerative disease or disorder with abnormal or altered endoplasmic reticulum-mitochondrial-associated membranes (ER-MAM) integrity.
Claims50
A method for determining whether a subject is predisposed to having a neurodegenerative disease or disorder, the method comprising:
- (a) obtaining a biological sample from a subject, and
- (b) testing the biological sample to determine whether it exhibits increased endoplasmic reticulum-mitochondrial-associated membrane integrity as compared to endoplasmic reticulum-mitochondrial-associated membrane integrity exhibited in a biological sample obtained from a non-affected individual.
A method for determining whether a compound ameliorates a neurodegenerative disease or disorder in a subject, the method comprising testing a test biological sample to determine the compound is capable of increasing endoplasmic reticulum-mitochondrial-associated membrane integrity.
Dependencies are inferred from the claim text.