Methods for diagnosing heart failure and other cardiac diseases
AssigneeThe Trustees of the University of Pennsylvania
InventorsBonnie Ky, Thomas Cappola, Douglas B. Sawyer
Life of this patent
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Abstract
The invention relates to methods of diagnosing the severity of heart failure or a cardiac dysfunction in a subject. The invention further relates to monitoring the severity of heart failure in a subject and determining the prognosis of a subject that has suffered from heart failure. This invention also relates methods to identify patients at risk for cardiac dysfunction when exposed to cardiotoxic chemotherapy agents.
Claims30
A method for diagnosing heart failure severity in a subject at risk for heart failure, said method comprising:
- obtaining a biological sample from said subject;
- analyzing said sample to determine the level of over-expression or under-expression of a biomarker associated with heart failure severity, and comparing said level of over-expression or under-expression to that of a pre-determined standard;
- wherein said biomarker is NRG-1β.
A method of monitoring response to therapy in a subject having suffered from heart failure said method comprising:
- obtaining a biological sample from said subject;
- analyzing said sample to determine the level of over-expression or under-expression of a biomarker associated with heart failure severity, and comparing said level of over-expression or under-expression to that of a pre-determined standard;
- wherein said biomarker is NRG-1β.
A method of providing a prognosis for a subject having suffered from heart failure, said method comprising:
- obtaining a biological sample from said subject;
- analyzing said sample to determine the level of over-expression or under-expression of a biomarker associated with heart failure severity, and comparing said level of over-expression or under-expression to that of a pre-determined standard;
- wherein said biomarker is NRG-1β.
A method for identifying a subject at risk of a chemotherapy-induced disease, said method comprising:
- obtaining a biological sample from said subject;
- analyzing said sample to determine the level of over-expression or under-expression of a biomarker associated with a cardiac dysfunction, and comparing said level of over-expression or under-expression to that of a pre-determined standard;
- wherein said biomarker is NRG-1β.
Dependencies are inferred from the claim text.