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AssigneesThe University of Tokyo, Keio University
InventorsTomoyoshi Soga, Masahiro Sugimoto, Makoto Suematsu, Masashi Honma, Takehito Yamamoto, Hiroshi Suzuki
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A normal person (i.e. a control) and liver diseases such as drug induced liver injury, an asymptomatic hepatitis B carrier, an asymptomatic hepatitis C carrier, chronic hepatitis B, chronic hepatitis C, liver cancer, a nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and simple steatosis (SS) are identified by measuring the concentrations of γ-Glu-X (X represents an amino acid or an amine) peptides or the levels of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value.
A liver disease marker for detecting an oxidative stress in a mammalian tissue, wherein the marker is one of γ-Glu-Gly, γ-Glu-Ala, γ-Glu-Ser, γ-Glu-Thr, γ-Glu-Taurine, γ-Glu-Ile, γ-Glu-Leu, γ-Glu-Asn, γ-Glu-Asp, γ-Glu-Gln, γ-Glu-Lys, γ-Glu-Glu, γ-Glu-Met, γ-Glu-His, γ-Glu-Phe, γ-Glu-Trp, γ-Glu-Arg, γ-Glu-Citrulline, γ-Glu-Tyr.
A liver disease marker, wherein the marker is a combination of a plurality of γ-Glu-X (X represents an amino acid or an amine) peptides.
A liver disease marker wherein the marker is a γ-Glu-X (X represents an amino acid or an amine) peptides and characterized by being used for distinguishing between a nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and simple steatosis (SS).
A method for measuring a liver disease marker, wherein one of γ-Glu-Gly, γ-Glu-Ala, γ-Glu-Ser, γ-Glu-Val, γ-Glu-Thr, γ-Glu-Taurine, γ-Glu-Ile, γ-Glu-Leu, γ-Glu-Asn, γ-Glu-Asp, γ-Glu-Gln, γ-Glu-Lys, Glu, γ-Glu-Met, γ-Glu-His, γ-Glu-Phe, γ-Glu-Trp, γ-Glu-Arg, γ-Glu-Citrulline, γ-Glu-Tyr in a sample is measured as a liver disease marker.
An apparatus for measuring a liver disease marker, comprising
A method for measuring a liver disease marker, comprising measuring one of γ-Glu-Gly, γ-Glu-Ala, γ-Glu-Ser, γ-Glu-Val, γ-Glu-Thr, γ-Glu-Taurine, γ-Glu-Ile, γ-Glu-Leu, γ-Glu-Asn, γ-Glu-Asp, γ-Glu-Gln, γ-Glu-Lys, γ-Glu-Glu, γ-Glu-Met, γ-Glu-His, γ-Glu-Phe, γ-Glu-Trp, γ-Glu-Arg, γ-Glu-Citrulline, γ-Glu-Tyr in a liver organ collected from a non-human mammal.
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