TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY
AssigneeAlcon Research, Ltd.
InventorsJon E. Chatterton, Abbot F. Clark
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Abstract
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a transferrin receptor (TfR). Therapeutic uses for the conjugates are also provided.
Claims27
A method of delivering an interfering RNA molecule to an eye of a patient, comprising administering to the patient an interfering RNA molecule-ligand conjugate, wherein the ligand can bind to a transferrin receptor (TfR).
An interfering RNA molecule-ligand conjugate, wherein the ligand can bind to a transferrin receptor (TfR).
Dependencies are inferred from the claim text.