Methods and uses of leptin in immune modulation and hepatocellular carcinoma

A method for the treatment of an immune-related disorder in a subject comprising administering to said subject an effective amount of leptin, any homologue, derivative, functional fragment of leptin, an expression vector comprising a nucleic acid sequence encoding for leptin or any functional fragments thereof, a protein, a peptide, an anti-idiotype antibody to leptin, or any combination of any of the foregoing.

31-46. (canceled)

A method for the treatment of an immune-related disorder in a subject comprising administering to said subject an effective amount of an antibody specific for leptin, a fragment of an antibody to leptin, an antibody to the leptin receptor, a fragment of an antibody to the leptin receptor, soluble leptin receptor, a fragment of leptin, a fragment of leptin receptor, a protein or peptide capable of inhibiting the expression of leptin, a nucleic acid or an oligonucleotide comprising sequences complementary to leptin or leptin receptor mRNA sequences, or any combination of any of the foregoing.

76-90. (canceled)

A therapeutic composition for the treatment of an immune-related disorder in a mammalian subject, wherein said composition comprises as an effective ingredient ex vivo educated autologous NKT cells capable of modulating the Th1/Th2 cell balance, and optionally further comprises a pharmaceutically acceptable carrier, diluent, excipient and/or additive.