US 2011/0256114 A1 · T-CELL RECEPTOR AND NUCLEIC ACID ENCODING THE RECEPTOR

Abstract

A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.

Claims17

Dependent claims

A recombinant polypeptide comprising:

a polypeptide consisting of an amino acid sequence shown in SEQ ID NO:
5 of Sequence Listing or
a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence,
the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO:
2 of Sequence Listing.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/167,414Filed 23 Jun 2011

Priority

JP 2005-26608813 Sep 2005

Published

20 Oct 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61P 35/00
Antineoplastic agents
C07K 14/705
From animals; from humans: receptors; Cell surface antigens; Cell surface determinants
A61K 40/11
Characterised by the cell type used: t-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer…
A61K 40/32
Characterised by the recombinant expression of specific molecules in the cells of the immune system: t-cell receptors [TCR]

T-cell receptor and nucleic acid encoding the receptor

Life of this patent

T-cell receptor and nucleic acid encoding the receptor

Life of this patent

Abstract

Claims17