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US 2011/0256065 A1Published application
Non-Isotopic Detection of Osteoblastic Activity In Vivo Using Modified Bisphosphonates
OwnerJohn V. Frangioniinventor
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Abstract
The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures.
Claims6
A contrast agent represented in the general formula [I] or pharmaceutically acceptable salts thereof:
- wherein
- D represents a fluorescent moiety;
- R represents a linking group that covalently links the dye (D) and bisphosphonate moiety;
- R1 represents H, —OH, or a halogen;
- and
- R2 represents, independently for each occurrence, a free electron pair, hydrogen, or a pharmaceutically acceptable counterion.
3 more elements
-14. (canceled)
A contrast agent comprising a bisphosphonate covalently linked to a near-infrared fluorescent moiety, wherein the contrast agent (a) has an extinction coefficient of at least 100,000 M−1cm−1 in aqueous medium, (b) has an LD50 of at least 100 mg/Kg in humans, and (c) has a half-life in the human body of at least 10 minutes.
-18. (canceled)
-28. (canceled)
Dependencies are inferred from the claim text.