Method and Apparatus for Improving Delivery of an Agent to a Kidney
AssigneeAbbott Cardiovascular Systems Inc.
InventorsMichael J. Leonard, Binh T. Nguyen
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Abstract
Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members.
Claims20
A method comprising delivering a solution having a concentration of a therapeutic agent to an organ having branched vessels wherein delivering comprises at least one step that improves the therapeutic agent concentration uniformity among the branched vessels.
A method comprising delivering a solution having a concentration of a therapeutic agent to an organ having branched vessels wherein delivering comprises at least one step that improves the therapeutic agent concentration uniformity among the branched vessels;
- wherein a step that improves the therapeutic agent concentration uniformity among the branched vessels comprises a step of
- normalizing the viscosity of the therapeutic agent solution towards that of blood;
- delivering a delivery catheter comprising a delivery port such that the deployed position of the delivery catheter causes the delivery port to be located downstream enough of any upstream arterial branches not leading to the organ to prevent substantial drug delivery down the upstream arterial branches and upstream enough of the organ to allow substantial mixing of the solution with the blood;
- delivering a delivery catheter comprising a delivery port with a geometry that causes increased mixing between the blood and therapeutic agent solution;
- delivering a delivery catheter comprising at least one delivery port and at least one diffusion member wherein the diffusion member fosters increased turbulence near or down-stream of the delivery port;
- decreasing the infusion rate of the therapeutic agent solution;
- or
- increasing the number of delivery ports;
- and
- wherein a step that improves the therapeutic agent concentration uniformity among the branched vessels means that
- the range of therapeutic agent concentrations delivered to the vessels is small enough so that the total drug delivery to the vessel that receives the highest concentration falls within the maximum therapeutic dose
- while the total drug delivery to the vessel that receives the lowest concentration is 100-300 percent of the minimum therapeutic dose.
A method comprising delivering a solution having a concentration of a therapeutic agent to an organ having branched vessels wherein delivering comprises at least one step that improves the therapeutic agent concentration uniformity among the branched vessels;
- wherein a step that improves the therapeutic agent concentration uniformity among the branched vessels comprises a step of
- normalizing the viscosity of the therapeutic agent solution towards that of blood;
- delivering a delivery catheter comprising a delivery port such that the deployed position of the delivery catheter causes the delivery port to be located downstream enough of any upstream arterial branches not leading to the organ to prevent substantial drug delivery down the upstream arterial branches and upstream enough of the organ to allow substantial mixing of the solution with the blood;
- delivering a delivery catheter comprising a delivery port with a geometry that causes increased mixing between the blood and therapeutic agent solution;
- delivering a delivery catheter comprising at least one delivery port and at least one diffusion member wherein the diffusion member fosters increased turbulence near or down-stream of the delivery port;
- decreasing the infusion rate of the therapeutic agent solution;
- or
- increasing the number of delivery ports;
- and
- wherein a step that improves the therapeutic agent concentration uniformity among the branched vessels means that
- the range of therapeutic agent concentrations delivered to the vessels is small enough so that the total drug delivery to the vessel that receives the lowest concentration exceeds the minimum therapeutic dose
- while the total drug delivery to the vessel that receives the highest concentration is 50-200 percent of the maximum therapeutic dose.
Dependencies are inferred from the claim text.