Polymer-conjugated albumin hydrogels for controlled release of therapeutic agents
AssigneeTechnion Research & Development Foundation Limited
InventorsDror Seliktar, Liat Oss-Ronen
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Abstract
A hydrogel system comprising polymer-conjugated albumin molecules is provided for controlled release delivery of therapeutic agents. The polymer is a functionalized synthetic polymer, preferably PEG-diacrylate. The polymer-conjugated albumin is preferably mono-PEGylated albumin. The hydrogel system may comprise a matrix to which the polymer-conjugated albumin molecules are linked via a functional group of the polymer. The matrix may be formed from the same polymer of the polymer-albumin conjugate.
Claims26
A hydrogel system for controlled release delivery of a therapeutic agent, wherein said hydrogel comprises polymer-conjugated albumin molecules.
A hydrogel composition for sustained release of a therapeutic agent, said composition comprising:
- (i) a synthetic polymer-conjugated albumin;
- (ii) a synthetic polymer capable of copolymerization with the synthetic polymer of (i);
- (iii) a therapeutic agent;
- and (iv) a photoinitiator.
Dependencies are inferred from the claim text.