Narcotic Drug Formulations with Decreased Abuse Potential
AssigneePaladin Labs Inc.
InventorsRobert Vinson, Patrick Gosselin, Aimesther O. Betancourt
Life of this patent
Estimating the term…
Abstract
The present application relates to novel narcotic formulations having a decreased injection abuse potential In a representative embodiment, the formulation comprises methadone hydrochloride (6-dimethylamino-4,4-diphenylheptan-3-one, a synthetic opiod), meglumine, cellulose, lactose, and magnesium stearate The application further illustrates methods for making the contemplated formulations.
Claims37
An oral drug formulation for reducing potential for abuse, the formulation comprising:
- a pharmaceutically acceptable salt of a narcotic drug, wherein the narcotic drug has a chemical structure that includes at least one positively charged protonated amine;
- and an alkalizing agent for reducing the solubility of the narcotic drug in a non-acidic solution, wherein the alkalizing agent comprises an amine containing compound selected from the group consisting of meglumine, monoethanolamine, diethanolamine and triethanolamine.
(canceled)
(canceled)
(canceled)
A drug formulation comprising methadone hydrochloride and meglumine, wherein methadone extraction with water is less than about 10% of the total methadone available in tablet form.
A drug formulation comprising methadone hydrochloride and meglumine, wherein methadone extraction in alcoholic solutions is less than about 50% of the total methadone available in tablet form.
(canceled)
A drug formulation comprising methadone hydrochloride and meglumine, wherein, when the formulation is crushed and exposed to small volume of water with stirring for 5 minutes at room temperature, less than about 5% by weight of the pharmaceutically active agent originally present in the formulation before it was crushed is released into the water.
A drug formulation comprising methadone hydrochloride and meglumine, wherein, when the formulation is crushed and exposed to a small volume of solution containing 95% (v/v) ethanol with stirring for 5 minutes at room temperature, less than about 50% by weight of the pharmaceutically active agent originally present in the formulation before it was crushed is released into the aqueous solution.
(canceled)
(canceled)
(canceled)
(canceled)
A method for reducing potential for abuse of a narcotic drug, the method comprising:
- providing to a patient an oral formulation of the drug, wherein the formulation comprises:
- a pharmaceutically acceptable salt of the narcotic drug comprising a chemical structure that includes at least one positively charged protonated amine;
- and an alkalizing agent for reducing the solubility of the narcotic drug in a non-acidic solution, the alkalizing agent comprising:
- an amine containing compound selected from the group consisting of meglumine, monoethanolamine, diethanolamine and triethanolamine.
Dependencies are inferred from the claim text.