Molecular Crystal of (4-(1,8-Naphthyridin-2-YL)Piperidin-1-YL)Pyrimidine Derivative
OwnerEric Phillips, Mohannad Shawerinventors
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Abstract
A molecular crystal form of (S)-3-(2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4-ylamino)-2-(4-methoxyphenylsulfonamido)propanoic acid is characterized by an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 7.44, 14.80, 16.64, and 23.04±0.2°. The molecular crystal can be formulated into pharmaceutical composition for treating or controlling diseases resulting from pathological angiogenesis.
Claims13
A molecular crystal form of a compound having Formula I, characterized by an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 7.44, 14.80, 16.64, and 23.04±0.2°
A pharmaceutical composition comprising a molecular crystal form of a compound having Formula I,
- wherein said molecular crystal is characterized by an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 7.44, 14.80, 16.64, and 23.04±0.2°.
A method for treating or controlling a disease resulting from a pathological angiogenesis, said method comprising administering to a subject, who suffers from, or is at risk of developing, said disease, a pharmaceutical composition comprising a molecular crystal form of a compound having Formula I, characterized by an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 7.44, 14.80, 16.64, and 23.04±0.2°
A method of producing a molecular crystal of a compound having Formula I,
- the method comprising subjecting a suspension comprising a compound having Formula I to an autoclaving condition at 121-125° C., about 100-120 kPa above atmospheric pressure, for 30 minutes to 10 hours, under a closed atmosphere generated by said aqueous suspension, wherein said molecular crystal is characterized by an X-ray powder diffraction (“XRPD”) spectrum that comprises peaks at 2θ angles of 7.44, 14.80, 16.64, and 23.04±0.2°.
Dependencies are inferred from the claim text.