Inhibitors of fatty acid binding protein (fabp)

A compound, or a pharmaceutically acceptable salt of said compound, the compound being represented by the general formula I:

• wherein:
• Y is a ring as described below;
• X is either:
• (i) C(R7R8), N(R3), S, S(O2), or O, and both are absent;
• or
• (ii) C(R7), and X is linked, either to the ring marked Y as shown by the towards the right of X, or to the position marked G on the triazolopyrimidinone ring as shown by the towards the left of X, to form a 3-8 membered cycloalkyl or a 4-8 membered heterocyclyl ring containing 1-3 heteroatoms independently selected from N, O and S, or
• (iii) N (with R3 being absent), and X is linked, either to the ring marked Y as shown by the towards the right of X, or to the position marked G on the triazolopyrimidinone ring as shown by the towards the left of X, to form a 4-8 membered heterocyclyl ring containing 1-3 heteroatoms independently selected from N, O and S, including the nitrogen atom of X;
• further wherein shown to the right of X is mutually exclusive of shown to the left of X;
• G is C(R6) when shown to the left of X is absent, and G is C when shown to the left of X is present;
• Ring Y is aryl, heteroaryl, heterocyclyl or cycloalkyl, and when shown to the right of X is present, a ring atom on Y is the point of attachment for said shown to the right of X, wherein each of said aryl, heteroaryl, heterocyclyl and cycloalkyl can be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, hydroxyl, alkyl, alkoxy, CN and CF3;
• R3 may be present or absent as stated above, and when R3 is present, R3 is H, alkyl or cycloalkyl, wherein each of said alkyl and cycloalkyl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, hydroxyl, alkoxy, CN and CF3;
• R1 is H, alkyl, -alkyl-OR4, haloalkyl, haloalkoxy or -alkyl-CN;
• m is 1-2;
• t is 0-4;
• each R2 is independently selected from the group consisting of halo, CN, —OW, alkyl, haloalkyl, haloalkoxy, aryl, heteroaryl, heterocyclyl, cycloalkyl, —NH2, —NH(alkyl), —NH(aryl), —NH(heteroaryl), —NH(cycloalkyl), —S-alkyl, —S-aryl, —S-heteroaryl, —S-cycloalkyl, —C(O)OH, —C(O)—NH2, —C(O)N(H)(alkyl), —C(O)N(H)aryl, —C(O)N(H)(heteroaryl), —C(O)N(H)(heterocyclyl), —C(O)—N(H)(cycloalkyl), —C(O)N(alkyl)2, —C(O)N(aryl)2, —C(O)N(heteroaryl)2, —C(O)N(heterocyclyl)2, —C(O)—N(cycloalkyl)2, —C(O)N(aryl)(alkyl), —C(O)N(heteroaryl)(aryl), —C(O)N(heterocyclyl)(heteroaryl), —C(O)N(aryl)(heterocyclyl), —C(O)—N(alkyl)(cycloalkyl), —C(O)N(cycloalkyl)(aryl), —C(O)N(cycloalkyl)(heterocyclyl), —NH—C(O)—NH2, —C(O)R5, and —C(O)OR5, wherein each of said alkyl, aryl, heteroaryl, heterocyclyl and cycloalkyl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, hydroxyl, cycloalkyl, alkoxy, —C(O)R5, CN and CF3;
• Z is H, —OR5, —C(O)OR5, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl or heteroaryl, wherein each of said alkyl, cycloalkyl, haloalkyl, aryl and heteroaryl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, CN, —OR5, alkyl, haloalkyl, haloalkoxy, aryl, heteroaryl, heterocyclyl, cycloalkyl, —C(O)—NH2, —C(O)N(H)(CH3), —NH—C(O)—NH2, —C(O)R5, and —C(O)OR5;
• R4 is H, alkyl, aryl or heteroaryl, wherein each of said alkyl, aryl and heteroaryl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituents being independently selected from the group consisting of halo, hydroxyl, alkoxy, CN and CF3;
• R5 is H, alkyl, cycloalkyl, aryl or heteroaryl, wherein each of said alkyl, cycloalkyl, aryl and heteroaryl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituents being independently selected from the group consisting of halo, hydroxyl, alkoxy, —OC(O)R4, CN and CF3;
• R6 is H, halo, alkyl, aryl or heteroaryl, wherein each of said alkyl, aryl and heteroaryl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituents being independently selected from the group consisting of halo, hydroxyl, alkoxy, CN and CF3;
• R7 is H, alkyl, hydroxy or alkoxy, wherein each of said alkyl and alkoxy may be independently unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, hydroxyl, alkoxy, CN and CF3;
• R8 is H, alkyl, hydroxy or alkoxy, wherein each of said alkyl and alkoxy may be independently unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, hydroxyl, alkoxy, CN and CF3;
• R9 is H, halo, alkyl, cycloalkyl, aryl or heteroaryl, wherein each of said alkyl, aryl and heteroaryl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituents being independently selected from the group consisting of halo, hydroxyl, alkoxy, CN and CF3;
• and
• R10 is H, halo, alkyl, cycloalkyl, aryl or heteroaryl, —C(O)OH, —C(O)—NH2, —C(O)N(H)(alkyl), —C(O)N(H)aryl, —C(O)N(H)(heteroaryl), —C(O)N(H)(heterocyclyl), —C(O)—N(H)(cycloalkyl), —C(O)N(alkyl)2, —C(O)N(aryl)2, —C(O)N(heteroaryl)2, —C(O)N(heterocyclyl)2, —C(O)—N(cycloalkyl)2, —C(O)N(aryl)(alkyl), —C(O)N(heteroaryl)(aryl), —C(O)N(heterocyclyl)(heteroaryl), —C(O)N(aryl)(heterocyclyl), —C(O)—N(alkyl)(cycloalkyl), —C(O)N(cycloalkyl)(aryl), —C(O)N(cycloalkyl)(heterocyclyl), —NH—C(O)—NH2, —C(O)R5, and —C(O)OR5, wherein each of said alkyl, aryl, heteroaryl, heterocyclyl and cycloalkyl may be unsubstituted or optionally independently substituted with one or more substituents which can be the same or different, each substituent being independently selected from the group consisting of halo, alkyl, aryl, heteroaryl, hydroxyl, cycloalkyl, alkoxy, —C(O)R5, CN and CF3;
• or alternatively, R9 and R10 can together form ═O or R9 and R10 can be joined to form a spirocyclyl group;
• with the proviso that the compound represented by Formula I excludes the following compounds: