Modulating and/or detecting activation induced deaminase and methods of use thereof
OwnerJavier M. Di Noia, Alexandre Orthweininventors
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Abstract
A method for stratifying a subject, said method comprising: measuring the AID expression and/or activity in a first sample of the subject, and comparing said expression and/or activity to a reference AID expression and/or activity, wherein an AID expression and/or activity in the first sample of the subject that is higher than the reference AID expression and/or activity is indicative that the subject would benefit from a treatment with at least one Heat Shock Protein 90 (Hsp90) inhibitor.
Claims24
A method for stratifying a subject, said method comprising:
- a. measuring the AID expression and/or activity in a first sample of the subject, and
- b. comparing said expression and/or activity to a reference AID expression and/or activity, wherein an AID expression and/or activity in the first sample of the subject that is higher than the reference AID expression and/or activity is indicative that the subject would benefit from a treatment with at least one Heat Shock Protein 90 (Hsp90) inhibitor.
A method for the prevention and/or treatment of an AID-associated disease in a subject in need thereof, said method comprising:
- a. measuring the level of AID expression and/or activity in a first sample from the subject,
- b. comparing said expression and/or activity to a reference AID expression and/or activity,
- wherein, if the AID expression and/or activity is higher in the first sample from the subject than the reference AID expression and/or activity, an effective amount of an Heat Shock Protein 90 (Hsp90) inhibitor is administered to the patient.
A method for preventing drug resistance in a subject having an AID-expressing neoplastic disease, said method comprising:
- a. measuring the level of AID expression and/or activity in a tissue sample from the subject, and
- b. administering an effective amount of an Hsp90 inhibitor in combination with the drug, to the subject having an AID-positive tissue,
- whereby the drug resistance is prevented.
A method for adjusting a dose of a Hsp90 inhibitor in a treatment, said method comprising:
- a. measuring the level of AID expression and/or activity in a sample of a subject treated with an Hsp90 inhibitor,
- b. comparing said expression and/or activity to a reference AID expression and/or activity from the subject at an earlier time, and
- c. administering to the subject having a substantially similar or higher AID expression and/or activity than the reference AID expression and/or activity an increased dose of the Hsp90 inhibitor.
A kit for preventing and/or treating an AID-associated disease or for stratifying a subject having an AID-associated disease comprising an AID ligand and a Heat Shock Protein 90 (Hsp90) inhibitor.
Dependencies are inferred from the claim text.