Method of ameliorating oxidative stress and supplementing the diet
AssigneeUniversity of Kentucky Research Foundation
InventorsBoyd E. Haley, Niladri Narayan Gupta
Life of this patent
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Abstract
A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a chemical structure: wherein R1 is an aromatic backbone and R2 is a sulfur containing ligand. Through formation of disulfide linkages other moieties can be attached to R2 converting the hydrophobic base into a water soluble entity, for ease of delivery, which can be reconverted back to the original compound by biochemical reduction in the blood stream.
Claims43
A method of supplementing a diet of a mammal, comprising:
- administering to said mammal a pharmaceutically effective amount of a compound having a chemical formula:
- where R1=
- and
- where R2=
- where R3=ethyl or methyl, R4=hydrogen, glutathione, cysteine, alphadihydrolipoic acid, cystamine, thiolphosphate, 5′thioladenosine, L-homocysteine, co-enzyme A, 2-mercaptoethanol, dithiothreitol, iodoacetate, bromoacetate, fluoroacetate or chloroacetate and n=2-4.
A method to remove heavy metals and toxins from a mammal, comprising:
- administering to said mammal a pharmaceutically effective amount of a compound having a chemical formula:
- where R1=
- and
- where R2=
- and
- where R3=ethyl or methyl, R4=hydrogen, glutathione, cysteine, alphadihydrolipoic acid, cystamine, thiolphosphate, 5′thioladenosine, L-homocysteine, co-enzyme A, 2-mercaptoethanol, dithiothreitol, iodoacetate, bromoacetate, fluoroacetate or chloroacetate and n=2-4.
A method of relieving oxidative stress in a mammal, comprising:
- administering to said mammal a pharmaceutically effective amount of a compound having a chemical formula:
- where R1=
- and
- where R2=
- and
- where R3=ethyl or methyl, R4=hydrogen, glutathione, cysteine, alphadihydrolipoic acid, cystamine, thiolphosphate, 5′thioladenosine, L-homocysteine, co-enzyme A, 2-mercaptoethanol, dithiothreitol, iodoacetate, bromoacetate, fluoroacetate or chloroacetate and n=2-4.
A pharmaceutical composition, comprising:
- a pharmaceutically effective amount of a compound having a chemical formula:
- where R1=
- and
- where R2=
- and
- where R3=ethyl or methyl, R4=hydrogen, glutathione, cysteine, alphadihydrolipoic acid, cystamine, thiolphosphate, 5′thioladenosine, L-homocysteine, co-enzyme A, 2-mercaptoethanol, dithiothreitol, iodoacetate, bromoacetate, fluoroacetate or chloroacetate and n=2-4;
- and
- a pharmaceutically acceptable excipient.
The composition of claim 339, wherein said additional dietary supplement is selected from a group of materials consisting of whey protein, N-acetylcystein, cysteine, glutathione, nicotine adenine dinucleotide (NAD+), reduced nicotine adenine dinucleotide (NADH), glycylcysteine (gly-cys), glutamylcysteine (glu-cyc), and combinations thereof.
A pharmaceutical composition, comprising:
- between about 99.5 and about 5 weight percent of a pharmaceutically effective amount of a compound having a chemical formula:
- where R1=
- and
- where R2=
- and
- where R3=ethyl or methyl, R4=hydrogen, glutathione, cysteine, alphadihydrolipoic acid, cystamine, thiolphosphate, 5′thioladenosine, L-homocysteine, co-enzyme A, 2-mercaptoethanol, dithiothreitol, iodoacetate, bromoacetate, fluoroacetate or chloroacetate and n=2-4;
- between about 0.0 and about 50 weight percent of an additional antioxidant;
- between about 0.0 and about 20 weight percent of a water soluble metal chelator;
- between about 0.0 and about 50 weight percent of glutathione;
- between about 0.0 and about 50 weight percent of an additional dietary supplement that supports glutathione synthesis;
- and
- between about 0.5 and about 50 weight percent of a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.