Insecticidal Polypeptides and Methods of Use Thereof
OwnerGlenn F. King, Brianna Sollod McFarland +2inventors
InventorsGlenn F. King, Brianna Sollod McFarland, Graham Nicholson, Simon Gunning
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Abstract
A family of insecticidal polypeptides expressed in the venom gland of spiders of the genera Atrax and Hadronyche have been described. Also included are polynucleotides and expression vectors encoding the polypeptides and insect viruses and cells expressing the polypeptides. Transgenic plants and insects expressing the insecticidal polypeptides are also described. The insecticidal polypeptides may be employed in methods and compositions for treating insects, insect larvae, and plants.
Claims19
-36. (canceled)
A purified polypeptide comprising an amino acid sequence having greater than or equal to about 80% identity to SEQ ID NO:
- 2, wherein said polypeptide has insecticidal activity.
A purified polypeptide comprising an amino acid sequence having greater than or equal to about 85% identity to any one of SEQ ID NOs:
- 8, 11, 14, 17, 20, 23 or 26.
An isolated polynucleotide encoding a polypeptide comprising an amino acid sequence have greater than or equal to about 80% identity to SEQ ID NO:
- 2, wherein the polypeptide has insecticidal activity.
An insect virus comprising a polynucleotide encoding a polypeptide comprising an amino acid sequence have greater than or equal to about 70% identity to SEQ ID NO:
- 2, wherein the polypeptide has insecticidal activity.
A method of treating an insect or an insect larva, comprising contacting the insect, the insect larva, or the insect's environment with an insecticidally effective amount of a U-ACTX polypeptide, wherein the U-ACTX polypeptide comprises an amino acid sequence that is greater than or equal to about 70% identical to SEQ ID NO:2, wherein the U-ACTX polypeptide has insecticidal activity.
Dependencies are inferred from the claim text.