Compositions of a v-atpase inhibitor in combination with a glucocorticoid receptor ligand and methods of use
OwnerHuaqiang Eric Xu, Yong Xu +1inventors
InventorsHUAQIANG ERIC XU, Yong Xu, Yuanzheng He
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Abstract
A composition of a glucocorticoid receptor (GR) ligand, or analog thereof, and a V-ATPase inhibitor, or analog thereof. A method for administering such composition to a cell either to increase glucocorticoid transrepression activity or to increase glucocorticoid transactivation activity in the cell. Also, a method for treating a subject having an inflammatory or auto-immune disease by administering such composition.
Claims20
A composition comprising:
- a) a glucocorticoid receptor (GR) ligand, its enantiomers, diasteromers, tautomers, prodrugs thereof, or pharmaceutically-acceptable salts or hydrates thereof, and
- b) a V-ATPase inhibitor,
- its enantiomers, diasteromers, tautomers, prodrugs thereof, or pharmaceutically-acceptable salts or hydrates thereof.
A method for increasing glucocorticoid transrepression activity in a cell comprising administering to a cell a V-ATPase inhibitor, its enantiomers, diasteromers, tautomers, prodrugs thereof, or pharmaceutically-acceptable salts or hydrates thereof, thereby increasing glucocorticoid transrepression activity in the cell.
A method for increasing glucocorticoid transactivation activity in a cell comprising administering to a cell a V-ATPase inhibitor, its enantiomers, diasteromers, tautomers, prodrugs thereof, or pharmaceutically-acceptable salt or hydrates thereof, thereby increasing glucocorticoid transactivation activity in the cell.
A method for treating a subject having an inflammatory or auto-immune disease comprising administering to a subject having an inflammatory or auto-immune disease a therapeutically effective dose of a V-ATPase inhibitor, its enantiomers, diasteromers, tautomers, prodrugs thereof, or pharmaceutically-acceptable salts or hydrates thereof, thereby treating the disease.
Dependencies are inferred from the claim text.