Back to results
US 2011/0237435 A1Published application
Lipophilic nucleic acid delivery vehicle and methods of use thereof
AssigneeChildren's Hospital & Research Center at Oakland
InventorRobert O. Ryan
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions and methods for delivery of nucleic acids to individuals and to cells, including nucleic acid delivery particles that comprising a lipid-binding polypeptide, a lipid bilayer comprising one or more cationic lipids, and a nucleic acid.
Claims56
A nucleic acid delivery particle comprising a lipid-binding polypeptide, a lipid bilayer, and a nucleic acid,
- wherein the total lipid content of the lipid bilayer is between about 5% and about 100% of one or more cationic lipids,
- wherein the interior of the lipid bilayer comprises a hydrophobic region,
- wherein the particle
- does not comprise an aqueous core,
- is disc-shaped with the hydrophobic edge of the lipid bilayer circumscribed by the lipid-binding polypeptide at the periphery of the particle, and
- remains disc-shaped in aqueous solution.
3 more elements
Dependencies are inferred from the claim text.