System and method for processing samples

A method for processing samples, the method comprising:

• providing a loading chamber;
• providing a detection chamber positioned in fluid communication with the loading chamber;
• providing a fluid path defined at least partially by the loading chamber and the detection chamber;
• positioning a sample in the loading chamber;
• filtering the sample with a filter positioned in the loading chamber to form a concentrated sample on the filter and a filtrate, the filter having an inlet and an outlet and positioned such that at least one of the inlet and the outlet is positioned in the fluid path, wherein filtering includes applying a pressure differential across the filter;
• removing the filtrate from the fluid path at a location upstream of the detection chamber;
• moving at least a portion of the concentrated sample from the filter in the fluid path to the detection chamber by centrifugation;
• and
• analyzing the at least a portion of the concentrated sample in the detection chamber for an analyte of interest.