L-arginine-based formulation for oral absorption

A method for treating cardiovascular disorders comprising steps:

• a. obtaining an l-arginine-based orally-obtained useful for dissolving fat plaques in the artery characterized by odor levels lower than 1 European Odor Units (ouE/m3) as obtained by olfactometry and wherein said formulation is capable of inducing nausea on a subject consuming at least 30 ml of said formulation per Kg weight of subject comprising an L-arginine-containing compound in a concentration ranging from about 1% to about 80% (w/w);
• wherein said formulation having a pH of about 7 is palatable such that it is sustainable in a subject's mouth for at least 3 seconds allowing adsorption of at least 70% of said L-arginine content into said subject's blood system comprising:
• i. an L-arginine-containing peptide comprising l-arginine in a concentration ranging from about 1% to about 80% (w/w);
• ii. acids which have an LD50 (oral rabbit) higher than 2 gm/kg;
• iii. organic solvents, which have an LD50 (oral rabbit) higher than 2 gm/kg;
• iv. flavoring additives;
• v. sequestrants consisting of materials having a log(Ki)>2 in which i represents the coordination number of the complex which is an integer between 1 and 4, and K represents the stability coefficient of said complex;
• vi. preservatives;
• and,
• vii. water;
• b. orally administering between about 5 ml to about 800 ml of said formula to a subject between once a week and five times a day;
• and,
• c. repeating step (b) over a period of three days to twenty four months.