Intravaginal drug delivery device
OwnerZe'ev Shaked, Klaus Nickisch +3inventors
InventorsZe'ev Shaked, Klaus Nickisch, James DiNunzio, Feng Zhang, Marcelo Omelczuk
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Abstract
Described herein is an intravaginal drug delivery system. In an embodiment the intravaginal drug delivery system includes a progestin and estrogen compound, and releases the active ingredients in a fixed physiological ratio over a prolonged period of time to produce a contraceptive state in a female.
Claims23
An intravaginal drug delivery device comprising:
- an uncoated thermoplastic matrix;
- and
- a progestin dispersed in the thermoplastic matrix.
A method of making an intravaginal drug delivery device comprising:
- forming a mixture of a thermoplastic polymer and a progestin;
- heating the thermoplastic polymer/progestin mixture such that at least a portion of the thermoplastic polymer is softened or melted to form a heated mixture of thermoplastic polymer and progestin;
- and
- permitting the heated mixture to solidify as a solid mass.
19-33. (canceled)
An intravaginal drug delivery device made by the method comprising:
- forming a mixture of a thermoplastic polymer and a progestin;
- heating the thermoplastic polymer/progestin mixture such that at least a portion of the thermoplastic polymer is softened or melted to form a heated mixture of thermoplastic polymer and progestin;
- and
- permitting the heated mixture to solidify as a solid mass;
- wherein the device comprises the progestin dispersed in an uncoated thermoplastic matrix.
35-50. (canceled)
A method of producing a contraceptive state in a subject comprising positioning an intravaginal drug delivery device in the vagina or uterus of a female, wherein the intravaginal drug delivery device comprises an uncoated thermoplastic matrix, and a progestin dispersed in the thermoplastic matrix.
52-82. (canceled)
Dependencies are inferred from the claim text.