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US 2011/0236411 A1Published application
MHC Multimers in Tuberculosis Diagnostics, Vaccine and Therapeutics
AssigneeDako Denmark A/S
InventorsJørgen Scholler, Liselotte Brix, Henrik Pedersen, Tina Jakobsen
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Abstract
The present invention relates to MHC-peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual. More specifically the invention discloses MHC complexes comprising Mycobacterium tuberculosis antigenic peptides and uses there of.
Claims29
A MHC monomer comprising a-b-P, or a MHC multimer comprising (a-b-P)n, wherein n>1,
- wherein a and b together form a functional MHC protein capable of binding the peptide P,
- wherein (a-b-P) is the MHC-peptide complex formed when the peptide P binds to the functional MHC protein,
- wherein each MHC peptide complex of a MHC multimer is associated with one or more multimerization domains.
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Dependencies are inferred from the claim text.