Treatment of fibrotic eye disorders using an mmp2 inhibitor
AssigneeUniversity of East Anglia
InventorsIan Michael Wormstone, Lucy Dawes, Julie Ann Eldred, Dylan Edwards, Lisa Hodgkinson
Life of this patent
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Abstract
Inhibitors of matrix metalloproteinase 2 are used to treat or prevent a fibrotic disorder of the posterior capsule of the eye, for example posterior capsule opacification (PCO), or of a tissue or structure of the eye other than the lens or capsular bag.
Claims18
Use, in a method for the treatment or prevention of a fibrotic disorder of the posterior capsule of the eye, or of a tissue or structure of the eye other than the lens or capsular bag, or in the preparation of a medicament therefor, of an active agent comprising an inhibitor of MMP2.
An active agent comprising an inhibitor of MMP2, for use in the treatment or prevention of a fibrotic disorder of the posterior capsule of the eye, or of a tissue or structure of the eye other than the lens or capsular bag.
A composition, for example a pharmaceutical composition (medicament), comprising an effective amount of an active agent comprising an inhibitor of MMP2, and one or more physiologically compatible carrier, diluent or excipient, for use in the treatment or prevention of a fibrotic disorder of the posterior capsule of the eye, or of a tissue or structure of the eye other than the lens or capsular bag.
An intraocular lens for use in ocular lens replacement surgery, wherein the lens has associated with it an active agent comprising an MMP2 inhibitor, for the treatment or prevention of a fibrotic disorder of the posterior capsule of the eye.
A kit for use in the treatment or prevention of a fibrotic disorder of the posterior capsule of the eye, or of a tissue or structure of the eye other than the lens or capsular bag, comprising a preparation of a first active ingredient which is an MMP2 inhibitor and a preparation of a second active ingredient, and optionally instructions for the simultaneous, sequential or separate administration of the preparations to a patient in need thereof.
Dependencies are inferred from the claim text.