In vivo chemical stabilization of vulnerable plaque

A composition comprising a biocompatible carrier, a collagen crosslinking agent and a VEGF growth factor, wherein composition has a concentration of the collagen crosslinking agent at least about 0.5 w/v %.

A medical device for delivery of a composition at a location in a blood vessel, the device comprising:

• a shaft comprising a balloon lumen, a permeable balloon supported by the shaft with an interior in fluid communication with the balloon lumen, and a reservoir holding a stabilization agent near the distal end of the shaft and being configured for controlled delivery of the stabilization agent to the balloon through the balloon lumen, wherein the stabilization agent comprises an elastin stabilization agent, a collagen stabilization agent, VEGF, or a combination thereof.

A medical device comprising a vascular isolation apparatus and a reservoir of VEGF, wherein the vascular isolation device comprises a sealing element operably connected with a catheter having a lumen with fluid passage between the reservoir and a fluid delivery port, the sealing member being configured for isolating a portion of a blood vessel when the catheter is delivered in a less invasive endovascular procedure, and wherein the fluid delivery port is positioned for delivery of fluid to the isolated portion of the blood vessel.