Biomarkers For The Identification, Monitoring, And Treatment Of Non-Small Cell Lung Cancer (NSCLC)
AssigneeOn-Q-ity
InventorsDavid T. Weaver, William E. Pierceall, Brian Ward
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Abstract
This present invention compositions and methods of treating, diagnosing, prognosing cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.
Claims22
A method for predicting the response to chemotherapy and/or survivability of a subject having a non-small cell lung cancer comprising
- a) measuring the level of an effective amount of one or more DNARMARKERS in a sample from the subject;
- and
- b) comparing the level of the effective amount of the one or more DNARMARKERS to a reference value.
A method of accessing the effectiveness of a chemotherapeutic agent treatment of a subject having a non-small cell lung cancer comprising
- a) measuring the level of an effective amount of one or more DNARMARKERS in a sample from the subject;
- and
- b) comparing the level of the effective amount of the one or more DNARMARKERS to a reference value.
A method of monitoring the a chemotherapeutic agent treatment of a subject with non-small cell lung cancer comprising
- a) detecting the level of an effective amount of one or more DNARMARKERS in a first sample from the subject at a first period of time;
- b) detecting the level of an effective amount of one or more DNARMARKERS in a second sample from the subject at a second period of time;
- and
- c) comparing the level of the effective amount of one or more DNARMARKERS detected in step (a) to the amount detected in step (b), or to a reference value.
An algorithm that is derived from any combination of biomarkers comprising the list of biomarkers in Table 1, Table 2, Table 3 or Table 4 which specifies how the biomarkers are associated in relation to the other biomarkers in the panel, such that the biomarker algorithm indicates a predictive or prognostic value in treatment response of head and neck cancer.
Dependencies are inferred from the claim text.