Two-step targeted tumor therapy with prodrug encapsulated in nanocarrier
AssigneeBionanox
InventorJun Chen
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Abstract
A two-step targeted tumor therapeutic method is described comprising nanocarrier with prodrug encapsulated thereto and prodrug activating enzyme. The enzyme is either encapsulated in nanocarrier, or not encapsulated, or synthesized in the tumor. With the method, the prodrug released from the nanocarrier is activated by the enzyme mainly in the tumor.
Claims34
A two-step targeted tumor therapy method comprising nanocarrier with prodrug encapsulated thereto, and enzyme to activate said prodrug, whereby said nanocarrier and enzyme are suspended in a solution for delivery into patient simultaneously or at different time points, and said prodrug released from said nanocarrier is activated by said enzyme mainly in the interstitial space of tumor.
A different two-step targeted tumor therapy method comprising nanocarrier with prodrug encapsulated thereto, and enzyme produced inside said tumor.
Another different two-step targeted therapeutic method comprising nanocarrier with prodrug encapsulated thereto and enzyme for treatment of inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, lupus erythematosus, and atherosclerosis, whereby said prodrug released from said nanocarrier is activated by said enzyme mainly in the inflammation sites of the inflammatory diseases.
Dependencies are inferred from the claim text.