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US 2011/0217351 A1Published application
Coating for medical implants
AssigneeSouthwest Research Institute
InventorsXingguo CHENG, Nitin NITIN, Jorge G. ROSSINI, Stephen T. WELLINGHOFF
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Abstract
A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.
Claims28
A method for coating the surface of an implant comprising:
- (a) coating the implant surface with a first layer of polymeric material that is either physically adhered and/or covalently bound to the implant surface;
- (b) coating the first layer of polymeric material with a second layer of polymeric material wherein the second layer of polymeric material includes a drug for delivery and wherein said second layer of polymeric material is either:
- (i) physically adhered to the first layer;
- and/or
- (ii) covalently bonded to the first layer;
- and/or
- (iii) joined to the first layer in the form of an interpenetrating polymer network;
- and
- (c) coating the second layer with a third outer layer wherein said third outer layer is either:
- (i) physically adhered to the second layer;
- and/or
- (ii) covalently bonded to the second layer;
- and/or
- (iii) joined to the second layer in the form of an interpenetrating polymer network;
- wherein said third layer has relatively higher mechanical strength than said first and second layers and is capable of hydration and said implant provides an initial cumulative drug release within 24 hours of administration of 0-95% and a sustained release of any remaining portion within a 14 day period.
12 more elements
A method for coating the surface of an implant comprising:
- (a) coating the implant surface with a first layer of polymeric material that is either physically adhered and/or covalently bound to the implant surface wherein said first polymer material includes surface functionality comprising amine, hydroxyl and/or carboxylic acid groups;
- (b) coating the first layer of polymeric material with a second layer of polymeric material wherein the second layer of polymeric material includes surface functionality comprising amine, hydroxyl and/or carboxylic acid and said second layer includes a drug for delivery and wherein said second layer of polymeric material is either:
- (i) physically adhered to the first layer;
- and/or
- (ii) covalently bonded to the first layer;
- and/or
- (iii) joined to the first layer in the form of an interpenetrating polymer network;
- and
- (c) coating the second layer with a third outer layer wherein said third outer layer is either:
- (i) physically adhered to the second layer;
- and/or
- (ii) covalently bonded to the second layer;
- and/or
- (iii) joined to the second layer in the form of an interpenetrating polymer network wherein said third outer layer comprises:
- wherein R1 is selected from a hydrogen, alkyl group and/or an aromatic ring;
- R2 is selected from:
- (1) an alkyl group wherein at least one hydrogen on the alkyl group may be substituted with a hydrophilic type functional group;
- (2) ether and/or polyether type functionality.
15 more elements
A method for coating the surface of an implant comprising:
- (a) coating the implant surface with a first layer of polymeric material that is either physically adhered and/or covalently bound to the implant surface and which includes a drug for delivery;
- (b) coating the first layer with a second outer layer wherein said second outer layer is either:
- (i) physically adhered to the first layer;
- and/or
- (ii) covalently bonded to the first layer;
- and/or
- (iii) joined to the first layer in the form of an interpenetrating polymer network;
- wherein said outer layer has relatively higher mechanical strength than said first layer and is capable of hydration and said implant provides an initial cumulative drug release within 24 hours of administration of 0-95% and a sustained release of any remaining portion within a 14 day period.
5 more elements
An implant comprising:
- (a) an implant substrate including an outer surface wherein the implant is selected from one of:
- (i) a polymeric material;
- (ii) a ceramic material;
- or (iii) a metallic material selected from the group consisting of Ti, Al, V, Cr, Fe, Co, Mo, Ni, Mn, Mg, Zr, and combinations thereof and/or stainless steels;
- (b) a first layer of polymeric material that is either physically adhered and/or covalently bound to the implant surface;
- (c) a second layer of polymeric material wherein the second layer of polymeric material includes a drug for delivery and wherein said second layer of polymeric material is either:
- (i) physically adhered to the first layer;
- and/or
- (ii) covalently bonded to the first layer;
- and/or
- (iii) joined to the first layer in the form of an interpenetrating polymer network;
- and
- (d) a third outer layer wherein said third outer layer is either:
- (i) physically adhered to the second layer;
- and/or
- (ii) covalently bonded to the second layer;
- and/or
- (iii) joined to the second layer in the form of an interpenetrating polymer network;
- wherein said third layer has relatively higher mechanical strength than said first and second layers and is capable of hydration and said implant provides an initial cumulative drug release within 24 hours of implantation of 0-95% and a sustained release of any remaining portion within a 14 day period.
16 more elements
An implant comprising:
- (a) an implant substrate including an outer surface wherein the implant is selected from one of:
- (i) a polymeric material;
- (ii) a ceramic material;
- or (iii) a metallic material selected from the group consisting of Ti, Al, V, Cr, Fe, Co, Mo, Ni, Mn, Mg, Zr, and combinations thereof and/or stainless steels;
- (b) a first layer of polymeric material including a drug for delivery wherein said polymer material is either physically adhered and/or covalently bound to the implant surface wherein said first polymer material includes surface functionality comprising amine, hydroxyl and/or carboxylic acid groups;
- (b) a second layer of polymeric material wherein said second layer is either:
- (i) physically adhered to the first layer;
- and/or
- (ii) covalently bonded to the first layer;
- and/or
- (iii) joined to the first layer in the form of an interpenetrating polymer network;
- and wherein said second layer comprises
- wherein R1 is selected from a hydrogen, alkyl group and/or an aromatic ring;
- R2 is selected from:
- (1) an alkyl group wherein at least one hydrogen on the alkyl group may be substituted with a hydrophilic type functional group;
- (2) ether and/or polyether type functionality.
13 more elements
Dependencies are inferred from the claim text.