Cycloalkyl containing thienopyrimidines for pharmaceutical compositions

A compound of Formula (I)

• wherein
• X is CH or N,
• R1 is a hydrogen or halogen atom,
• R2 is C3-7 cycloalkyl group that is substituted with one or two substituents selected from oxo, halogen, C1-3 alkyl, hydroxy, C1-3 alkoxy, C1-4 alkoxy-carbonyl, amino and morpholinyl,
• wherein the hydrogen atoms of the amino group may optionally be independently replaced by a C1-3 alkyl, C1-3 alkoxy-(CH2)m—, C1-4 alkoxy-carbonyl, C1-3 alkylsulfonyl, C1-3 alkyl-carbonyl, C3-6-cycloalkyl-carbonyl or piperidinyl group, wherein m is 2 or 3 and wherein the piperidinyl group may optionally be substituted by a methyl group,
• wherein two substituents, which are attached to the same carbon atom, together may form a —O—(CH2)2—O— group, and
• wherein two substituents, which are attached to two adjacent carbon atoms, together may form a —O—CH2—O— or —O—C(CH3)2—O— group,
• R3 is a C1-2 alkyl group and
• R4 is a carboxy, C1-3 alkoxy-carbonyl, aminocarbonyl, N—(C1-4 alkyl)-aminocarbonyl or N,N-[di-(C1-4 alkyl)]-aminocarbonyl group,
• wherein the aminocarbonyl group may be substituted with a C1-3 alkylsulfonyl, CN, OH, C1-3 alkoxy, C3-6 cycloalkyl, —CH2—C≡C—CH2—NH2, —CH2—C≡C—CH2—NH(C1-3 alkyl) or —CH2—C≡C—CH2—N(C1-3 alkyl)2 group or with a piperidinyl or pyrrolidinyl group bound via a carbon atom,
• and
• wherein the alkyl moieties of the above-mentioned N-(C1-4 alkyl)-amino-carbonyl and N,N-[di-(C1-4 alkyl)]-aminocarbonyl groups may optionally be substituted with an aminocarbonyl, N-(C1-3 alkyl)-aminocarbonyl or N,N-[di-(C1-3 alkyl)]-aminocarbonyl group or with a pyrrolidinyl, oxazolyl, imidazolyl, piperidinyl or morpholinyl group, each bound via a carbon atom, or, from position 2 of an ethyl, propyl or butyl moiety onwards, with a OH, CN, C1-3 alkoxy, amino, N-(C1-3 alkyl)-amino, N,N-[di-(C1-3 alkyl)]-amino, C1-5 alkyloxy-carbonyl-amino, morpholino, piperidino, piperazino, pyrrolidino, azetedinyl, aziridinyl or imidazolyl group,
• wherein each of the above-mentioned cycloalkyl, pyrrolidinyl, oxazolyl, piperidinyl, morpholinyl, piperazinyl and imidazolyl groups may be substituted with a methyl, amino, hydroxy group or C1-3 alkoxy,
• or a pharmaceutically acceptable salt thereof.