US 2011/0217248 A1 · Topical Composition

Abstract

Topical compositions are disclosed that are useful for delivering a therapeutic level of an NSAID to a target within a subject having a local inflammatory disorder. A composition of the present invention comprises a Drug and a solvent system, wherein the solvent system comprises at least two solvent alcohols and wherein the solvent system is present in an amount sufficient to solubilize the Drug, the solvent system is a low alkanol system, and the composition is a single phase composition. Examplary solvent systems are those for which one of the at least two solvent alcohols is polyethylene glycol, glycerin, butylene glycol, diproylene glycol, propylene glycol, ethanol, isopropanol, or a derivative therof. Optionally the local inflammatory disorder is pseudofolliculitis barbae, dermatitis, psoriasis, wounds, or sunburn.

Claims19

Dependent claims

A composition comprising an NSAID, a solvent system, and from zero to about 60% alkanol, wherein

(i) the solvent system comprises at least two solvent alcohols;
(ii) one of the at least two solvent alcohols is a polyethylene glycol, a propylene glycol, glycerin, polyether polyol, butylene glycol;
or a glycerol derivative;
(iii) the solvent system has at least about a 20% super solvent effect;
(iv) the solvent system is present in an amount sufficient to solubilize the NSAID;
(v) the NSAID is in an amount of about 12% to about 30%;
and
(vi) the composition is single phasic.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/944,014Filed 11 Nov 2010

Priority

6 Sep 2006

Published

8 Sep 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification35 codes

A61K 31/192
Carboxylic acids, e.g. valproic acid: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/08
Medicinal preparations characterised by special physical form: solutions
A61K 31/167
Having aromatic rings, e.g. colchicine, atenolol, progabide: having the nitrogen of a carboxamide group directly attached to the aromatic ring,…

Family

Application60/824,642Us provisional application · filed 6 Sep 2006

Application60/893,888Us provisional application · filed 9 Mar 2007

Application11/842,201Continuation · filed 21 Aug 2007

Application12/944,014Continuation

US 2008/0317684 A1Published application

US 2011/0217248 A1This patent

From the US filing history. Foreign family members aren’t listed.

Topical Composition

Life of this patent

Topical Composition

Life of this patent

Abstract

Claims19