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AssigneesChildren's Medical Center Corporation, Massachusetts Institute of Technology, The General Hospital Corporation D/B/A
InventorsTodd R. Hoare, Daniel S. Kohane, Robert S. Langer, Mikhail G. Shapiro, Yoon Yeo, Grace Y. Kim, Shahriar R. Khushrushahi
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The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.
An article containing a magnetically-susceptible material at least partially defining an enclosure containing a releasable species, wherein application of an oscillating magnetic field to the magnetically-susceptible material causes at least some release of the releasable species externally from the enclosure.
(canceled)
15-16. (canceled)
An article containing a magnetically-susceptible material at least partially defining an enclosure containing a releasable species, wherein application of an oscillating magnetic field to the magnetically-susceptible material causes an increase of release of the releasable species of at least about 10% from the implantable article, relative to the amount of release of the releasable species from the article in the absence of oscillating magnetic field.
23-25. (canceled)
An article comprising a magnetically-susceptible material at least partially defining an enclosure containing a releasable species, the magnetically-susceptible material being in thermal communication with a heat-sensitive material, wherein application of an oscillating magnetic field to the magnetically-susceptible material causes the heat-sensitive material to increase in temperature by at least about 0.5° C.
27-64. (canceled)
Dependencies are inferred from the claim text.