Urea derivatives as antibacterial agents

A compound represented by Formula (I)

• or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein:
• (i) T is selected from the group consisting of H, alkyl, alkenyl and alkynyl, wherein said alkyl, alkenyl and alkynyl can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocyclyl, heterocyclenyl, heterocycloalkylalkyl, heterocyclenylalkyl, —OH, alkoxyl, —O-alkenyl, —O-alkynyl, hydroxyalkyl, hydroxyalkenyl, —O-aryl, —O-aralkyl, —SH, —S-alkyl, —S-alkenyl, —S-alkynyl, —S-aryl, —S-aralkyl, —NR1R2, -alkyl-NR1R2, -alkenyl-NR1R2,
• wherein R1 and R2 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkenyl, aralkyl, cycloalkylalkyl, cycloalkenylalkyl, heteroaryl, heteroaralkyl, or
• R1 and R2 together with the N atom to which each is attached form heterocyclyl, heterocyclenyl, or heteroaryl;or
• T and H together with the C atom to which each is attached form spirocycloalkyl or spiroheterocyclyl, wherein each of said spirocycloalkyl and spiroheterocyclyl can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cycloalkenyl, cycloalkyl, aralkyl, aralkenyl, cycloalkenylalkyl, cycloalkylalkyl, halo and haloalkyl;
• (ii) X is O, S or NH;
• (iii) R4 and R5 are independently selected from the group consisting of hydrogen or (C1-C6)alkyl, wherein said (C1-C6)alkyl is substituted with aryl wherein said aryl can be unsubstituted or optionally independently substituted with alkynyl, halo, aryl, heteroaryl, heterocyclenyl or heterocyclyl, wherein said alkynyl, heteroaryl, heterocyclenyl or heterocyclyl can be unsubstituted or substituted with an additional aryl;
• or
• R4 and R5 together with the N atom to which each is attached, form a heterocyclyl or heterocyclenyl, wherein each of said heterocyclyl and heterocyclenyl is substituted with A;
• or
• R4 and R5 together with the N atom to which each is attached form a heterocyclic structure represented by the structure:
• wherein Y, Q, Z, or V are each independently selected from the group consisting of C(O), C(S), C(NH), S(O), S(O)2 and C(R6R7), wherein q is 0-1, wherein each of R6 and R7 are independently selected from the group consisting of H, alkyl, and alkenyl, wherein each of said alkyl or alkenyl can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, cycloalkenyl, cycloalkyl, aralkyl, aralkenyl, cycloalkenylalkyl, cycloalkylalkyl, halo and haloalkyl;
• further wherein M is N or CR, wherein R is H, halo, alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkenyl, cycloalkyl, heteroaryl, heterocyclenyl, heterocyclyl, OH, —O-alkyl, —O-alkenyl, —O-alkynyl, —O-aryl, —O-aralkyl, —O-cycloalkenyl, —O-cycloalkyl, —O-heteroaryl, —O-heterocyclenyl, —O-heterocyclyl, —SH, —S-alkyl, —S-alkenyl, —S-alkynyl, —S-aryl, —S-aralkyl, —S-cycloalkenyl, —S-cycloalkyl, —S-heteroaryl, —S-heterocyclenyl, or —S-heterocyclyl;
• A is selected from the group consisting of, -aryl-alkynyl-aryl, -aryl-C(O)aralkyl, -aryl, -biaryl, -alkynyl-aryl, -aryl-heteroaryl and -aryl-alkynyl-heteroaryl, wherein said , -aryl-alkynyl-aryl, -aryl-C(O)aralkyl, -aryl, -biaryl, -alkynyl-aryl, -aryl-heteroaryl, and -aryl-alkynyl-heteroaryl can be unsubstituted or optionally independently substituted with one or more moieties selected from the group consisting of halo, haloalkyl, —N(R1)(R2), haloalkoxyl, -alkyl-CN, hydroxyalkyl, —OH, heterocyclyl, heterocyclenyl, alkyl, alkenyl, dialkylaminoalkoxyl and heterocyclylalkoxyl.