Use of microparticles containing genetically modified cells in the treatment of neurodegenerative diseases

A method for the treatment of a neurodegenerative disease in a subject in need thereof comprising the administration to said subject of a microparticle comprising genetically modified cells expressing at least one neurotrophic factor, at least one angiogenic factor or a combination of both wherein the microparticle is administered at the cerebral cortex level without damaging the cerebral cortex.